Emerging Technologies for Molecular Therapy for Intervertebral Disk Degeneration
نویسندگان
چکیده
منابع مشابه
Gene therapy for intervertebral disk degeneration.
Intervertebral disk degeneration is a common and potentially debilitating disease process affecting millions of Americans and other populations each year. Current treatments address resultant symptoms and not the underlying pathophysiology of disease. This has spawned the development of biologic treatments, such as gene therapy, which attempt to correct the imbalance between catabolism and anab...
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Intervertebral disk degeneration has been considered an irreversible process characterized by a decrease in cell viability, attenuation of proteoglycan and type II collagen synthesis, and dehydration of nucleus pulposus. Stem cell therapy specifically addresses the degenerative process and offers a potentially effective treatment modality. Current preclinical studies show that mesenchymal stem ...
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ژورنال
عنوان ژورنال: Orthopedic Clinics of North America
سال: 2011
ISSN: 0030-5898
DOI: 10.1016/j.ocl.2011.07.004